Life Science

Water analysis of pharmaceutical water, as Purified Water (PW), Highly Purified Water (HPW) or Water for Injection (WFI) is of special concern in the life science industry regarding product quality and safety in process.

Depending on the res­pec­tive ap­pli­ca­tion, re­quire­ments re­gar­ding UPW purity are de­fined in norms as well as pharma regulations (pharmacopoeia).

Types of Water

  • Process water
  • Pure water (PW)
  • Highly purified water (HPW)
  • Water for injections (WFI)
  • Ultra-pure water (UPW)

Process Control and Product Safety

In the pharmaceutical sector water is inter alia used as

  • Cleaning agent
  • Excipient
  • Ingredient
  • Raw material and much more

Depending on its usage, pharmaceutical water needs a certain purity. 
Requirements on water quality and monitoring equipment are high.

  • Water for injections (WFI) is a demanding application of UPW in the pharmaceutical industry. In the manufacture of any type of active ingredient and medicine, the entire production process, including the cleaning process, is seamlessly monitored.
  • Highly purified water (HPW) is used as cleaning agent
  • Ultra-pure water (UPW) is often used as process water for the production of pills, capsules and other oral medication.

Purification of water

  • Even drinking water or potable water contain organics and other substances in very low concentration
  • pharmaceutically used water needs to be purified before it is used in manufacturing processes
  • The treatment of this so-called feedwater or make-up water takes place on-site and is very costly

Comparison of phamaceutical water Limits

Purified WaterHighly Purified WaterWater for Injection
USPEPUSPEPUSPEP
TOC500 ppb≤ 0,5 mg/lN/A≤ 0,5 mg/l500 ppb≤ 0,5 mg/l

Need further information?

Related news for pharma industry

Total Organic Carbon analysers are commonly used to measure the level of organic contamination in water. Online TOC analysers installed in refineries and petrochemical plants are located right in the middle of the process facilities.

MÁS...